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Wednesday, 16 November 2011

SIP System

Steam in place system or SIP systems are widely used pharmaceutical sterilizers. Safety is of utmost concern in the pharmaceutical industry. All products are manufactured under strict aseptic conditions in compliance with statutory requirements.
Steam-in-place or SIP system is widely used for in-line sterilization of various processing equipments. It is one of the most popular sterilization system used in the pharma industry.
 
The SIP Process
One of the most widely used methods for creating a sterile environment in pharmaceuticals manufacturing is the use of heat in the form of steam to get rid of unwanted organisms. Though there are other methods of sterilization done by dry heat sterilizers or ETO sterilizers, recently CIP and SIP methods have become very popular. Steam-In-Place (SIP) is a sterilization method that involves sterilizing by way of steaming the interior of vessels, pipes, process equipment, and associated fittings, without disassembly.
 
Importance of SIP System
 The process of manufacturing and handling various pharmaceutical solutions and mixtures lead to cleaning and sterilizing these equipments regularly as they are susceptible to contamination. Proper SIP integration with pharmaceutical equipment is very important for the overall success of the operation. SIP is used for the in-line sterilization of vessels, valves, process lines, filter assemblies etc.
 
 
Advantages
  • SIP provides a very effective, convenient and above all a safe form of sterilization.
  • The steaming system is easy to automate and validate.
  • SIP relies on the reduction of manipulations and aseptic connections that might compromise the integrity of pharmaceutical processing.
  • The specific components include pressure regulators, steam traps, and sterilizing vent filters to remove air and condensate, and to cool down, dry, and maintain the sterility of the pharmaceutical equipment following sterilization.
 
Application of SIP System
  • Pharmaceutical Industry
  • Dairy Industry
  • Beverage Industry
  • Biotechnology Industry