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Friday, 28 October 2011

Manufacturing

Manufacturing
Equipment and processing in pharma, biopharma, specialty & generic drug manufacturing. Aseptic processing, cytotoxic manufacturing, small & large molecules.

Hot Melt Extrusion (HME) - nano-scale compounding developments

October 25, 2011

Hot melt extrusion is emerging as a preferred manufacturing methodology for dosage forms. The high cost and limited availability of raw materials during the development phase has resulted in the need to process small amounts of API's/excipients via extrusion to determine process viability. Experimental data is presented on a new twin screw extrusion device that can process as little as 20 to 100 gram micro-batches, as well as a scale-up path. 

Humidity measurement in cleanrooms: The devil is in the details

October 25, 2011

Systems used for measuring and monitoring RH play a small role in the overall picture of controlling cleanroom conditions, but problems inherent in humidity sensing can cause significant headaches for cleanroom operators. This article describes some observations and insights that are relevant to anyone in the cleanroom community who has struggled with humidity issues.

Monitoring Systems: Sorting out Wireless

October 25, 2011

Monitoring systems for temperature, humidity and other parameters can be complex, involving hundreds of sensors in a variety of applications. One of the most important decisions in selecting or adding to a monitoring system is choosing the connectivity method that will allow the sensors to speak to a central processing unit. Decisions on connectivity are dependent upon several factors, including: data integrity requirements for regulatory purposes, logistical concerns such as access points for transmitters, and existing network infrastructures. In this article, we describe the most common wireless methods of connecting sensors to a monitoring system and offer eight considerations for selecting a method best suited to the application. 

Seven Secrets to a Successful Auction

October 25, 2011

Have you been elected to close your facility? Or do you have idle assets in your facility that need clearance? Selecting the right auction partner can be difficult. We created a Better Auctions Resource Center and an eBook, “Seven Secrets to a Successful Auction”, as tools to guide you through this process. 

Steps for Reducing Glass Delamination

October 19, 2011

Equipment and Processing Report
Recent recalls have contributed to the pharmaceutical industry?s heightened awareness of glass delamination (i.e., the formation of glass flakes in a vial), which could affect drug quality and patient safety. To confront this growing problem effectively, drugmakers must understand its causes. 

Scaling Up a Tableting Process

October 19, 2011
Equipment and Processing Report
When I run a small production batch of a particular formulation with the same tablet press used to develop it, I get compressibility and disintegration issues. What am I doing wrong? 

Isolated Robotics: The Future of Aseptic Operations

October 19, 2011

Equipment and Processing Report
The future, and increasingly the present, for aseptic operations is isolated robotics. Companies that wish to gain competitive advantages in their operations are stepping up and taking notice. 

October 2011 Editor's Picks: Products from Edwards and Moyno

October 19, 2011
Equipment and Processing Report
PharmTech's monthly newsletter, Equipment and Processing Report, reviews the Editor's Picks for the October 2011 edition from Edwards and Moyno. 

Global Healthcare on the Ground: AAPS on Why Global HealthCare is Important Now

October 2, 2011

Pharmaceutical Technology
AAPS Global Health Focus Group's Kishor M. Wasan discusses new initiatives.